Lipoic Acid 300 mg
The antioxidant nature of lipoic acid is by far its best-understood activity. It seems to be capable of “recharging” vitamin C, E, glutathione, and potentially CoQ10 and directly quenching many reactive oxygen species (ROS).
Perhaps the most common clinical use for Lipoic Acid has been in the treatment of patients with diabetes.
Lipoic acid has been used to treat diabetic- induced neuropathies for over 30 years in Germany and more clinical trials exist for lipoic acid and the treatment of diabetic neuropathies (peripheral and cardiac) than any other outcome. It is thought to work by increasing microcirculation5, and improving the neurovascular reflex arc6.
As the eye tissue is the most susceptible to oxidative damage, antioxidants are vital to treat and prevent eye diseases like cataracts and macular degeneration. Vitamin C, E and glutathione (all of which are recharged by lipoic acid) are at very high doses in eye tissues.
Use of lipoic acid in patients with glaucoma has also been found to be of some success at 150 mg/day for 1 month8.
As a diverse molecule, lipoic acid has applications that range from patients suffering from HIV, liver diseases (including acute liver poisoning by mushroom toxins), exposure to radiation, CHF, atherosclerosis and many more.
Diabetes, Diabetic Neuropathy, Anti-oxidant, Eye Disease, HIV, Liver Disease, Radiation Exposure, Congestive Heart Failure (CHF) and Atherosclerosis
The range of dosing is quite broad depending on the use. Low-dose supplementation with other antioxidants is typically 50-200 mg per day, while some of the doses used to treat diabetic neuropathy were 800mg/day and even some as high as 600 mg three times per day.
Contraindication, Adverse or Other Reactions
The safety of many doses of lipoic acid over long periods of time has been excellent. No known side effects have been reported.
In animals- lipoic acid administration has been linked with the reduction of biotin-requiring enzymes. A result that is eliminated by administering biotin with lipoic acid9. While this problem is not known to happen with normal clinical doses in humans, precautionary levels of biotin have been added to this product.
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